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Welcome to JNCASR

Check out the programmes and their status:
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Welcome to JNCASR

Check out the programmes and their status:

Objectives & Deliverables


Objectives:


Deliverables:


Salient Features


Progress till date


Technology Readiness Level (TRL)

TRL-0

Key Players (Collaboration)


Challenges


Objectives & Deliverables


Objectives:


Deliverables:


Salient Features


Progress till date

Installed a microfluidic platform and fabricated a PDMS based microchannel device to observe flow of spherical and non-spherical particles.

Technology Readiness Level (TRL)

TRL-0

Key Players (Collaboration)


Challenges


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Objectives & Deliverables


Objectives:


Deliverables:


Salient Features

Using microphysical processing and modelling, a numerical tool has been designed to detect onset of fog over runways in the airport. Project is aimed to develop capability to predict occurrence of fog (at least 3 hrs. prior to onset) over airport area.  

Progress till date


Technology Readiness Level (TRL)

TRL-0

Key Players (Collaboration)


Challenges


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Objectives & Deliverables

The rice stem borer, Scirpophaga incertulas, and citrus leafminer, Phyllocnistis citrella are key pests of rice and citrus respectively (Fig.1 a&b). Cryptic nature of these pests makes it difficult for pesticide molecules to reach the target area. Moreover, indiscriminate use of the pesticides is a concern to consumers, environment and non-target organisms. A control program that is directed against adults by exploiting the pheromone has potential to limit the population build-up in addition to reducing the damage. Currently pheromone is loaded into a polymer membrane, polythene vials, rubber/ silicone, foam and capillary tubes. These matrices have high release rates and the efficacy of the pheromone loaded into the lures cease before the end of cropping season and warrants frequent replacement which scales up the cost involved in chemistry and labor. This demand a focus on delivery of pheromone via alternate routes.

Objectives:

  • Developing a nanomatrix for delivery of pheromone of rice stem borer, Scirpophaga incertulas and citrus leafminer, Phyllocnistis citrella.
  • Establishing the physiological and behavioral response of pheromone released from nanomatrix.
  • To establish field efficacy of pheromone loaded into nanomatrix so as to aid in pest management.
  • Identification a porous matrix for release of pheromone of rice stem borer, Scirpophaga incertulas, and citrus leafminer Phyllocnistis citrella

Deliverables:

  • The pheromone blend of citrus leaf miner to be formulated.

Salient Features

  • The filed evaluation of carbon nanomatrix loaded with semiochemicals (pheromones) caused attraction of adult male rice stemborer moths.

Progress till date

  • The adult rice stem borer female released sex pheromone (Z)-9-hexadecenal and (Z)-11- hexadecenal (9:1) was formulated.
  • The physiological response of antennal neurons of adult rice stemborer males to sex pheromone was established using electroantennography Fig.2.
  • A carbon and silica based nanomatrix has been developed for loading the insect pheromone (Fig.3).
  • The physiological and behavioral response of rice stem borer to pheromone released from nanomatrix established.

Technology Readiness Level (TRL)

TRL-5

Key Players (Collaboration)

  • ATGC Biotech Pvt. Ltd. Hyderabad

Challenges

  • Establish physiological and behavioural response of adult citrus leaf miner.
  • Evaluate field efficacy of citrus leaf miner loaded in nanomatrix.
  • Estimate release kinetics of pheromone.
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Objectives & Deliverables

With molecular detection gaining rapid importance in clinical, agriculture and animal husbandry related applications, and in academic research, it has become necessary to identify cost-effective, logistically simpler a method for detection of nucleic acids. The technique being developed hinges on the concept of surfaceenhanced Raman scattering (SERS) signal amplification. The project brings together three laboratories with complementary expertise in different areas needed for the execution of the concept.

Objectives:

  • Develop diagnostic technique based on SERS for the direct detection of the nucleic acids without template amplification, to minimize false positive.
  • Design specific HIV capture probes and detector probes for diagnostics to circumvent the problem of the viral genetic variation, and possible RNA degradation

Deliverables:

  • Develop a nucleic acid detection technique as a substitute for existing techniques such as PCR and Branched DNA technology

Salient Features

  • This technique has a sensitivity to detect 100 copies of a target template RNA or DNA in a reaction that does not require the template amplification and shows high sensitivity and specificity
  • Method can be a suitable alternative for PCR where clean laboratory facilities are not available.

Progress till date

  • Designed and developed a simplified miniaturized Raman spectrometer with facility for scanning 96 well plate.
  • The concept of dendritic Raman markers have been demonstrated
  • Vector identification has been achieved
  • Synthesis and procurement of oligonucleotide and magnetic nano particles with the right Raman probe completed
  • Clinical studies have commenced

Technology Readiness Level (TRL)

TRL-5

Key Players (Collaboration)

  • Horiba India Pvt. Ltd.; Tismo Technology Solutions Pvt. Ltd.

Challenges

  • Optimization for detection and quantification of HIV-1 RNA from clinical samples as proof-of-concept.
  • Further enhancement of the SERS signal through deft designing of the dendrimers carrying the Raman marker molecules and usage of gold nanoparticles for improved binding are underway.
  • Developing a product that is more cost effective than PCR and other known detection techniques.
  • Explore use in non-medical applications such as, detecting SNPs and pesticides will have to be explored.
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Objectives & Deliverables

Solution processed PVs (SPV) will be a primary emphasis for the proposed solar cell technologies which will make use of semiconducting polymers, small-molecule organic compounds, quantum-dots, organic-inorganic hybrid perovskite as photoactive materials.

Objectives:

  • Testing of large area SPVs and the design of portable, light-weight mobile SPV integrated products.
  • Incorporate 3D conformal-electrodes from low melting alloys which will reduce interfacial barriers and enhance energy conversion making these SPV solar modules all the more efficient.
  • Develop a tool for large area scanning of the photocurrent obtained from a photovoltaic device in order to examine the uniformity of the device and its degradation process. Identify degradation due to electrode delamination, oxygen and water diffusion, edge vs centre regions, hotspots and weak spots in the solar cell with these measurements.

Deliverables:

  • Demonstration of low-cost solar simulators and manufacture of large area solution processible solar cells
  • Design portable, light weight mobile PV integrated products
  • Provide packaged solution for PV research and development community for examining and scanning large area panels which is need for defect analysis and degradation studies

Salient Features

  • Intelligently designed scanning routines have been combined the with fast data acquisition using active synchronization and large volumes of data processing to allow a portable, high-speed photocurrent scanning system
  • Use of state-of-the-art third-generation photovoltaic (PV) materials utilizing non-conventional semiconductors, especially in the form of semiconducting polymers, small-molecule organic compounds, quantum-dots and organic-inorganic hybrid perovskite as photoactive materials, in the design and production of viable solar cell technologies.

Progress till date

  • By employing a whole assemblage of LED arrays, the group has successfully demonstrated the design of a LED based solar simulator for a 6x6 cm2 area solar cell by implementing an initial 6x6 array of white highpower LEDs.
  • The group has used a LED studded aluminium plate in conjunction with miscellaneous focusing optics and dye embedded polymer sheets to generate an analog light source of luminosity 340K lux.
  • The group has designed a new fully automated set-up to successfully characterize a PV solar cell device using this large area rapid scanning method.
  • The project has culminated with the development of a prototype product matching global standards with several innovative features.

Technology Readiness Level (TRL)

TRL-6

Key Players (Collaboration)

  • ISRO, Bangalore; EmVEE, Bangalore. This technology would be spun off as a company.

Challenges

  • Employ more sophisticated measurement techniques that will aid PV manufacturers, PV installers or importers as well as academic researchers in adopting new strategies for fabricating even more efficient PVs and PV-incorporated solar modules.
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Objectives & Deliverables

Systemic candidiasis is a life-threatening disease, predominantly caused by several species of Candida, which largely affects the immune- compromised individuals and patients in intensive care. This work focuses on developing easy and quick detection methods based on centromere sequences specific for Candida species.

Objectives:

  • Develop unique mode of the Polymerase Chain Reaction (PCR) technique based on unique centromere sequences for rapid identification of specific Candida infections.

Deliverables:

  • Design species-specific primers for a panel of pathogenic species causing nosocomial infections including C. albicans, C. tropicalis, C. glabrata, C. dubliniensis and C. lusitaniae
  • Validate the primers on mass-spectrometry verified clinical isolates of the species in question.
  • Establish the detection accuracy using patient samples from hospitals to determine accuracy and sensitivity of the assay.

Salient Features

  • The method was found to be sensitive and could detect as low as four cells when present in blood.

Progress till date

  • Developed species specific primers that can be used in multiplex PCR showing high sensitivity.
  • Sensitivity of DNA isolation method has been enunciated in Box B. Box C shows that the method is able to isolate and identify each unique Candida species.
  • Granted US Patent "Polynucleotide sequences of C. dubliniensis and probes for detection (US 20110159512 A1) application number: US 13/061,937PCT number: PCT/IN2008/0007602" and filed an Indian Patent on "Polynucleotide sequences of C. tropicalis and its use as probes for detection" Application number: 201641002369 (Indian Patent).

Technology Readiness Level (TRL)

TRL-5

Key Players (Collaboration)

  • Siemens Healthcare Pvt. Ltd.

Challenges

  • Test the method's detection accuracy vis-a-vis massspectrometry in clinical isolates
  • Examine its efficacy in clinical samples collected from real patients in hospitals
  • Develop method to detect Candida from minimum amount of patient blood.
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Objectives & Deliverables

The ever-rising demand for energy is primarily addressed using earth’s renewable sources, out of which only a handful fraction of it is utilized and a much larger portion (greater than 70%) of it is wasted as form of heat. Thermoelectric (TE) devices thus are centric for global sustainability as it utilizes the waste heat to generate electricity. The work here aims to use the waste heat to design TE devices that can provide total-package solution to mitigate environmental crisis and energy needs as a potential frontrunner for energy management in near future.

Objectives:

  • Identification of low cost promising p- and n-type TE materials, which exhibit high TE figure of merit (zT) in small scale synthesis (~2 g) in lab;
  • Scale up synthesis (~100 - 200 g) of high performance TE materials by mechanical alloying and Spark Plasma Sintering (SPS);
  • Measurement of TE properties of the SPS processed materials in order to check the consistency of high ZT and composition homogeneity, which are indeed important for next step, i.e. module development;
  • Testing of mechanical stability (micro-hardness) and thermal cycle stability of the scaled-up TE product;
  • Simulation of device efficiency (η) and development of real small-scale device for demonstration to industry partner.

Deliverables:

  • Design of devices (e.g. Prototype of stove made) that can use the waste heat
  • Use waste heat to run a fan without any external sources, by which one can enhance the combustion of woods and make the stove smoke less.

Salient Features

  • Identified low cost promising p- and n-type TE materials, which exhibit high ZT value for small scale synthesis at lab scale (~2 gms).

Progress till date

  • Identified low cost promising p- and n-type TE materials, which exhibit high ZT value for small scale synthesis at lab scale (~2 gms);
  • Scaled up synthesis of high performance TE materials (~75 gms) by mechanical allowing and Spark Plasma Sintring;
  • Measured zT value within 10% error for p-type materials;
  • Tested mechanical (microhardness) and thermal cycle stability of the scaled-up TE material;
  • Measured preliminary single leg device efficiency (useful for demonstration);
  • A stove that works based on the principle of thermoelectricity has been designed and fabricated;
  • High zT (~1.8 – 2.2) lead-free materials are being synthesized on consistent basis to fabricate high efficient and environmental friendly TE modules.

Technology Readiness Level (TRL)

TRL-4

Key Players (Collaboration)

  • GrowTech Innovations India Pvt. Ltd.

Challenges

  • Access to TE device fabrication and efficiency testing facility;
  • Module/device development for power generation;
  • Fixing a LED light near the stove that will glow by TE power.
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Objectives & Deliverables

Platinum or Platinum-based alloys supported on a carbon base are the traditional metals of choice as catalysts for both cathodic and anodic electrochemical reactions in polymer electrolyte membrane-based (PEM) fuel cells (FC) or PEMFCs. Such fuel cells are ubiquitous in various modern-day green energy technologies. However, Pt being a high-cost metal and also susceptible to carbon monoxide (CO) poisoning that happens to be one of the byproducts in the underlying electrochemical reaction, a low-cost non-Pt based nanostructures that are not just highly active but also more stable may offer an alternative. Development of highly efficient and robust non-Pt based electro catalysts based on small organic molecules (SOMs) with higher oxygen reduction reaction (ORR) is crucial for boosting the scope of current FCs.

Objectives:

  • Development of Pd-based binary and/or ternary ordered intermetallic nanoparticles as efficient electro catalysts for both small organic molecule oxidation and ORR in acidic as well as alkaline medium in a FC;
  • Varying size, shape and morphology of the ordered nanostructures to increase efficiency and stability;
  • Following the synthesis of the most promising catalysts for both reactions, intend to run a full-cell test to check their robustness for device fabrication and commercialization.

Deliverables:

  • Synthesize Pd based binary and/ or ternary ordered nanomaterials alloyed with transition metal and p-block elements which will be effective in oxidation and reduction process in fuel cell in both acidic and alkaline medium.

Salient Features

  • Ordered Pd based intermetallic binary and /or ternary nanoparticles (the noble metals alloyed with transition metals or P-block elements) are ideal for developing durable and efficient cathode and anode electrode material

Progress till date

  • The group is well on their way to synthesizing as well as characterizing these Pd based binary and/or ternary ordered intermetallics, shown in Fig. 1. For in-situ real world FC studies, where it is crucial to counter any poisoning effect in order to gain long-term stability, they have explored other p-block elements such as Selenium (Se) too. The synthesized chalcogenides shows remarkable stability over as many as 50,000 running cycles.
  • As is evident from Fig. 2 above, the study has so far set up an experimental FC combining both anode and cathode.

Technology Readiness Level (TRL)

TRL-4

Key Players (Collaboration)

  • Reliance Industries Ltd.
  • Tata Power

Challenges

  • Investigation of the mechanistic details of SOMs oxidation and ORR at the Pd surface to design FCs with more advanced electrode material.
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Objectives & Deliverables

Climate change due to greenhouse gas (GHG) emission from everyday combustion of carbonaceous fossil fuels such as coal, petroleum or natural gas is an extremely serious problem confronting humanity as a whole. Amongst these GHGs the most damaging is carbon dioxide (CO2). Catalytic conversion of the emitted CO2 to value added chemicals (methane, methanol, formaldehyde, formic acid, carbon monoxide) either by heterogeneous or homogeneous catalysis, may be the best economically viable route to recycle CO2 reducing CO2 emission and also as an added bonus, our dependence on fossil fuels. There are no standard technologies available to efficiently convert CO2 directly from the flue gas due to its mixed constituents and also the presence of water vapour, all factors likely to poison and decompose the catalyst within a short operational time. So, we aim to:

Objectives:

  • provide an integrated approach (Figure) to demonstrate industrial scale CO2 reduction to methanol from the flue gas coming out of coal power plants;
  • design better catalysts and engineer more suitable reactor systems to make the conversion scheme viable and practical at a large scale;
  • identify the ideal catalysts for the most efficient CO2 reduction using combined information obtained from experiments, first-principle calculations and data-driven machine-learning algorithms on alloys/ intermetallics/ bimetallics/core-shell nano-sized materials based on low cost metals.

Deliverables:

  • Demonstrate industrial scale CO2 reduction to methanol from the flue gas coming out of coal power plants.
  • Design better catalysts and engineering more suitable reactor systems to make the conversion scheme viable and practical at a large scale

Salient Features

  • The basic idea is to obtain industry scale thermochemical reduction of CO2 originating from coal and natural gas power plant to valuable products like methanol and CO.

Progress till date

  • The most relevant suitable catalysts have been screened, identified/developed and synthesized at lab scale;
  • The upper lab scale (5 kg) reactor has been designed and fabricated wherein the catalysts identified/developed were tested;
  • Based on lab scale process, a pilot scale reactor (500 kg) have been designed and currently being fabricated;
  • The technology has been competing globally with other technologies as a part of a global $20 million NRG COSIA Carbon XPRIZE Competition (hosted by the XPRIZE Foundation, USA), and emerged as one of the 5 finalists – the only one team from Asia.

Technology Readiness Level (TRL)

TRL-5

Key Players (Collaboration)

  • This technology has been shortlisted as one of 5 finalists (only finalists from Asia) of the Global $20 million NRG COSIA Carbon X Prize Competition, hosted by the X Prize Foundation, USA. Discussions are also in process to commercialize this technology through a spin-off viz. Breathe Applied Sciences Pvt. Ltd.

Challenges

  • To achieve targeted purity of methanol: >99.5 wt%;
  • Integration of CO2 reduction process with other complementary processes like CO2 capture, catalyst synthesis, hydrogen generation and product purification;
  • Based on the results of pilot scale demonstration, the process will have to be tested and optimized at 2 ton/ day level.
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Objectives & Deliverables

Surgical site infections (SSI) are the most common hospital acquired infections (HAI) related to surgical procedures; responsible for increasing cost, substantial morbidity and occasional mortality. The medical community has long felt the need for materials whether physical or chemical or a mixture of both, that can be applied to the directly or indirectly damaged tissue during surgery, acting as a wound sealant while also preventing infection. Our group developed syringe deliverable injectable hydrogels as a sealant with intrinsic antimicrobial activity using aqueous/buffered solutions of an antibacterial polymer (polymer 1) and a bioadhesive polymer (polymer 2).

Objectives:

  • Preparation of water-soluble antibacterial polymers from a naturally occurring polymer called chitosan, and in-vitro studies of its antibacterial power, and haemolytic and general cytoxicity levels.
  • Usage of porcine skin to determine adhesive property
  • Determine gel’s in-vivo efficacy in preventing sepsis.

Deliverables:

  • Synthesis and characterisation of bio adhesive polymers and development of the final injectable hydrogel combining the polymers synthesised at step 1 and 2.
  • Evaluation of in-vivo toxicity and in-vivo activity levels by injecting the hydrogel subcutaneously to mice.

Salient Features

  • The developed gel is antibacterial (including drug resistant strains) with capacity to seal wounds.

Progress till date

  • Developed two polymers, one being the adhesive and the other antibacterial (Fig. a and b).
  • The components were shown to form a gel within 30 seconds upon mixing their aqueous solutions (Fig. c) thus improving upon their previous synthesis.
  • The gel showed 95% bacterial growth inhibition with respect to control (Fig. d).
  • Once formed, the gel was shown to act based on contact based mechanism. It killed bacteria within 60 min upon contact (Fig. e).
  • The mice treated with the gel showed no sepsis and showed very high survival rates (80%) compared to control (only 12.5%) (Fig. f).

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

  • Discussions are in progress to out-license this invention to Vipragen Biosciences Pvt. Ltd.

Challenges

  • Influence of individual components and their relative content percentages on the hydrogel’s properties for formulation of an optimal concentration in the synthesized hydrogel, that can set at a rate conducive to typical surgical delivery.
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Objectives & Deliverables

Materials that phosphoresce naturally at room temperatures, otherwise known as RTP materials, have several potential applications in modern-day display devices, solid-state lighting with high luminescence power and various sensors. Most organic molecules even though endowed with a long lived stable triplet state, are not highly efficient due to their susceptibility to vibrational quenching, and difficulty in achieving the correct band gap for applications targeting the NIR or infra-red range. These two drawbacks in purely organic molecules make the aforementioned applications difficult to realize. So, we aim to:

Objectives:

  • Develop processable, metal free room temperature phosphorescent organic compounds on solid or polymer substrates
  • Identify the carbonyl group- as taking center stage in organic molecules showing RTP
  • Development of molecules which can link to hydrophilic polymers via hydrogen bonds and thus self-aggregate to minimize the vibrational quenching effects

Deliverables:

  • Develop new chromophores that can achieve emission over a range of visible wavelengths especially the ones spanning from red to NIR and which can be incorporated to polymer matrices or other templates to achieve room temperature, solution processable phosphorescent materials.

Salient Features

  • The fluorescence quantum yield setup for measurement of absolute photoluminescence and phosphorescence yield was custom assembled in the laboratory and this setup will be available and accessible to all researchers in JNCASR and TRC partner

Progress till date

  • Range of molecules synthesized, at lab scale. The ultimate form of the phosphor molecules have been envisioned to have the characteristics as given in Fig. 1
  • Observed molecules with specific design features embedded in them such as the inclusion of aldehyde and halogen-functionalities
  • Molecules synthesized in a fashion to augment conjugation in their chemical structure and shift the quantum band gap to a lower value thus building up the quantum yield.
  • Carboxylic acid functionality at the terminals, ideal for hydrogen bonding interactions with hydrophilic polymers such as PVA (poly vinyl alcohol)
  • Red shifted phosphorescence emission from an organic material with a special structure where the triplet quantum energy of a molecule is harvested by a second molecule within the same supramolecular structure leading to radiation in the high IR rangethese contain the same carboxylic acid end groups so that they can bind to a polymer matrix making them resistant to quenching via oxidation or humidity. (Fig. 2)
  • Synthesized organic bromo- or suphur substituted NDI phosphors (Fig.3)
  • Measurement system was designed and built to evaluate the fluorescence and phosphorescence quantum yield. This unit is functioning and providing accurate information.

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

  • Discussions are in process with Philips India Limited, Bangalore

Challenges

  • Integration into actual devices
  • Design a second family of molecules with TADF (Thermally activated delayed fluorescence) properties that have wide applications in latest 3rd generation OLED devices.
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Objectives & Deliverables

The broader concept of the proposal is the design and synthesis of materials for energy storage, generation and conversion. The materials involved are either organic or inorganic-organic hybrid porous polymers. We have focused our efforts for storing hydrogen, and photo- and electro-chemical water splitting for generating clean energy. Furthermore these materials have potential to act as bi-functional catalysts for oxygen evolution (OER) and oxygen reduction reactions (ORR) and find applications in regenerative fuel cells and metal air batteries. Porous organic polymers, particularly conjugated microporous polymers (CMPs) are promising materials for energy storage, light- harvesting and photocatalysis. They are low dense and possess excellent thermal/chemical stability due to strong C-C linkages.

Objectives:

  • synthesis of new CMPs with integrated luminescent receptor units, either covalently incorporated as part of the network or non- covalently bound to the CMP
  • use donor-acceptor building blocks to synthesize new CMPs and synthesizing different types organic porous polymers and H2 Storage.

Deliverables:

  • design and synthesis of novel CMP systems for H2storage applications, with tuneable pore surfaces with immobilization of various functional groups such as amines, hydroxo and
  • doping of different alkali metal for H2 adsorption and photosensitizing molecular complexes and stabilization of catalytically active metal/metal oxide nanoparticles like Pt, TiO2 and quantum dots like CdS and CdSe for photocatalysis applications

Salient Features

  • CMPs are very useful in gas storage, light-harvesting and photocatalysis. They are low dense and possess excellent thermal/chemical stability due to strong C-C linkages.

Progress till date

  • Photochemical Hydrogen production: Synthesis of donor-acceptor CMPs as a potential way to tune the band gap for increase the solar energy harvesting towards photochemical water splitting.
  • Designed and synthesized a series of metal free donoracceptor CMPs [tetraphenylethylene (TPE) = donor and 9-fluorenone (F) = acceptor], F0.1CMP, F0.5CMP and F2.0CMP which exhibited tunable band gaps (2.8 eV to 2.1 eV) by increasing the 9-fluorenone c ontent (Scheme 1).
  • Eletrochemical Oxygen evolution: Designed and synthesized an azo functionalized POP (NDI_PG) via diazo coupling of redox active naphthalene diimide (NDI) based diamine with phloroglucinol. The postsynthetic metalation of NDI_PG with Co" resulted Co"NDI- PG which was exploited for OER electrocatalyst.
  • Designed and synthesized two CoII-phthalocyanine (PC) based redox active metal-organic conjugated microporous polymers (Co-CMP), which is obtained by Schiff base condensation reaction.
  • CoCMP, where Co2+ was stabilized by N4-coordination of PC, showed stable and efficient electrocatalytic activity towards OER with a low overpotential of 340 mV.
  • Electrochemical Oxygen Reduction: A design strategy to fabricate electrochemically active CMPs by linking donor nodes (tri-phenylamines) and acceptor (biphenyl or tetraphenylethene) spacers (Scheme 1). The two new CMPs were structurally well characterized and show semi-conduction and redox-activity. Both the CMPs showed appreciable ORR activity and catalytic stability over time. This work showed the potential application of pristine metal-free CMPs in energy conversion process.

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

  • Under discussion with Reliance Industries

Challenges

  • Studies of H2 storage capacity of CMPs at different conditions like by varying temperature and pressure.
  • Design and synthesis of new materials with immobilization of different active functional groups on the pore surface for increasing isosteric heat of adsorption of H2;
  • Studies (photo and photo-electrochemical) on these materials toward bi-functional (HER and OER) activities (artificial photosynthesis) and tri-functional activities (HER, OER and ORR).
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Objectives & Deliverables

Alzheimer’s disease (AD), a devastating neurodegenerative disorders accounts for 70-80% of all dementia globally. The progressive loss or deterioration of cognition, task performance ability, mood, speech, behavior and memory is attributed to amyloid beta (Aβ) plaque deposition in the brain. To develop diagnostic and therapeutic tools for treating AD, studying Aβ production and aggregation and ways to clear it from the brain is critical. Current AD diagnosis is traditional – still based on behavioral tests or cognition in patients. So, the project aims to:

Objectives:

  • Develop molecular tools and hemicyanine based probes for in vitro and in cellulo detection and treatment of Aβ plaques
  • Methods and protocols to study and monitor the above and also their concentration levels/ratios.
  • Use of the developed probes to understand various stages of disease progression.

Deliverables:

  • Show efficacy of the developed probes in detection of Aβ plaques

Salient Features

  • The lead probe candidates have a high affinity for Aβ plaques and switch on NIR fluorescence capable of crossing Blood Brain Barrier.

Progress till date

  • The probes developed show specific binding to Aβ 42 aggregates
  • Data with the probes show promise in being superior to commercially available probes

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

  • This technology is being commercialized through a JNCASR created start-up, viz VNIR Biotechnologies Pvt. Ltd. which has been selected as one of the top- 100 start-ups of Karnataka (through Elevate Program of Government of Karnataka).

Challenges

  • Design and develop highly selective probes for monomeric and oligomeric Aβ plaques.
  • Standardize parameters to understand the binding affinity of the lead probe candidates and switch-on NIR fluorescence.
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