Standard approach to stimulating human nerve cells uses electrical current.Optical nerve stimulation overcomes many of the problems like pain associated with electrical stimulation: it requires no physical contact with the nerve cells. Light source can be tuned to precisely hit a small desired area.The project will focus on the feasibility of optical neural stimulation.
The extra cellular matrix, from tissues of animal origin after removal of unwanted cells, has a rich load of natural bio-molecules that promote tissue regeneration. This makes the extracellular matrix an excellent choice for enhanced wound healing.
MRSA is a bacterium that is tougher to treat because it is resistant to some commonly used antibiotics.A microbial strain which produces an antibacterial agent which is active against MRSA has been isolated. Project aims at detailed characterization of this antimicrobial molecule.
An Implantable Cardioverter Defibrillator (ICD) is a battery-powered device implanted under the skin of the chest, which is able to perform cardioversion, defibrillation and pacing of the heart.Cardioversion is a procedure by which an abnormally fast heart rate (tachycardia) or other cardiac rhythm disorders are treated using electrical signals. Defibrillation is a treatment for life-threatening cardiac fibrillation (unsynchronized contraction of heart muscles) using electrical shocks.
Embolization involves the selective occlusion of blood vessels by purposely introducing emboli and is used to treat a wide variety of conditions affecting different organs of the human body like aneurysm, tumor isolation etc. The objective of the project is to develop an indigenous technology for radiopaque polymeric microspheres intended for embolization therapy.
The basic appeal of oral hypoglycaemic agents is that most people would prefer a pill or an oral liquid to an injection. However, insulin is a hormone, which is digested in the stomach and gut.The project attempts to develop a strategy for oral delivery of insulin by suitably encapsulating to protect it during its traverse through the stomach.
An implantable micro infusion pump which can deliver drug to the region of interest such as peritoneal cavity, spinal cord etc. Battery operated device will have a drug reservoir and a miniature drive mechanism for delivering the drug through a catheter . Refilling of drug can be achieved by injecting through a specific port. The device will be powered by a battery which can be recharged by transcutaneous energy transfer system (TETS) thereby avoiding percutaneous wires and associated infections.
Hydrocephalus is the condition in which the cerebrospinal fluid (CSF) is accumulated within the brain. Hydrocephalus is treated by a surgical operation in which a shunt which connects the brain region to the peritoneal cavity. Current generation devices incorporate a predefined opening pressure valves. The proposed device will have a capability to program its opening pressure after implanttion.
Aims to develop a 3 Dimensional dermal-epidermal functional skin construct. A polymer ink based fabrication using 3D bio printing techniques used for encapsulating skin cells likekeratinocytes, fibroblasts and melanocytes for skin regeneration.
Extracorporeal Cardiopulmonary Bypass is a technique where the patient heart has to be stopped or bypassed during open heart surgery.The functions of the heart and lungs will be replaced by blood pump and oxygenator respectively. Roller pumps are cost effective for bypass, but causes blood damage.Centrifugal blood pump reduces blood damage substantially. Blood flow meter is used for measuring the flow output from the pump
A mechanical pump used to support heart function in patients who have weakened hearts. The device takes blood from the left ventricle of the heart and helps pump it to the body and vital organs, just as a healthy heart would.This can be used in patients waiting for heart replacement or patients having problems during surgery where heart will recover if it is allowed to relax for few days.
Used as an alternative to conventional surgical repair of aortic aneurysms (localized blood filled balloon like bulge in the wall of large arteries).The device is tubular fabric structure with metal reinforcement which can be delivered to the site using catheters .The patient recovers fast and it requires only a shorter period of hospital stay.
Parkinson’s disease (PD) patients suffer from a variety of movement related disorders such as tremors, stiffness of limbs, slowness of movements and poor balance. Low energy electrical stimulation of certain regions of brain using electrodes implanted in the brain controls these symptoms.Deep Brain Stimulator employs a pulse generator and a set of platinum electrodes to achieve the required effects.
Presence of White Blood Cells (WBC) in transfused blood could result in transmission of viral infection, immune suppression and transfusion related lung injury. Leuko-reduction is the removal of white blood cells (or leukocytes) from the transfused blood. The device employs special membranes which attracts and traps WBC as blood passes through it.
The Annuloplasty ring is a rigid or flexible ring implanted around the mitral valve for reconstructive treatment of valvular insufficiency. The implanted device enhances leaflet coaptation while preserving the native annular shape and motion.
Artificial heart valves are devices used for replacing diseased / damaged natural valves of the heart. Bio prosthetic heart valves are artificial valves made from materials of biological origin and are preferred in elderly patients.
Instability of lower spine vertebrae due to spondylosis (spinal degeneration) and spondylitis (inflammatory arthritis) often lead to crippling pain.Pain relief is achieved surgically by fusing the unstable portion of the spine or immobilizing the vertebral motion segment. The device helps in joining vertebral bodies through natural healing.
Bone and joint infections (Osteomyelitis) remain one of the most dreaded complications of orthopaedic surgery. Project aims at the development of a bioactive material platform, which has tuned porosity and osteoconductivity which can be used for in situ drug loading and delivery.
Epileptic seizures are the result of excessive and abnormal nerve cell activity in the certain regions of brain.Intracranial electrodes are used for locating the epileptogenic regions of brain. They help to locate the regions that need to be removed by surgery for controlling epilepsy.
Products extracted from human blood and meant for various therapeutic applications. These include albumin, Factor VIII and Intravenous Immunoglobulin (IVIG).The products will be validated to meet the requirements of European / Indian Pharmacopoeia.
The incidence of cartilage injury or damage is quite common and may be traumatic or degenerative. The aim of the project is to develop injectable hydrogel for repairing damaged cartilages.The gel can also be used as a vehicle to transport cartilage producing cells to the site.
The evaluation of potential liver toxicity represents a crucial step in the development of new drugs.Laboratory animals are used for carrying out these tests. The 3D liver constructs can be used for preliminary screening of drugs for their liver toxicity and help reduce the use of laboratory animals for drug toxicity assays.
The polymeric wound dressing for in situ loading of antibiotics. Gives the clinician the freedom to choose the drug of choice.
Develop a decellularised matrix from animal tissues. The extracellular matrix from gall bladder will be developed for wound healing applications.
The project aims at development of a non – toxic medical dressing having a high fluid holding capacity. It will be fast wicking and lint free, even when cut or trimmed. The medical dressing will have application in highly exudating chronic wounds.
Growth factors are substances secreted by the body whose function is to stimulate the growth of the cells involved in wound healing and inflammation.The project will be focusing on two recombinant growth factors, for its potential application in wound healing.
Skin tissue engineering approaches using an electro spun biodegradable polymer scaffold with appropriate degradation profile and physico – chemical properties will be developed as a scaffold.Upon its implantation, undesirable contraction of the wound could be prevented.
An Atrial Septal Defect (ASD) is an opening or a hole in the wall that separates the two upper chambers of the heart, the atria. Conventional management technique is open heart surgery to close the hole.
Abnormal communication between small arteries and veins within the brain are described as arterio – venous malformation resuling in seizures, intracranial bleeding, paralysis, visual loss etc. Such defects are sealed with special sealants which set on contact with blood. A non-metallic sealant is planned in the project. This will help improve MRI compatibility.
Intracranial aneurysm is a condition in which weakness in the wall of a cerebral artery causes a localized dilation or ballooning of the blood vessel. Flow diversion is an endovascular technique whereby the device is placed in the parent blood vessel to divert blood flow away from the aneurysm.