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Welcome to SNBNCBS

Check out the programmes and their status:
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Welcome to SNBNCBS

Check out the programmes and their status:

Objectives & Deliverables

Helicobacter pylori (H. pylori) is the leading cause of gastric ulcer and duodenal cancer. The "gold-standard" detection method for H. pylori infection is endoscopy-based biopsy tests. These methods are painful, invasive and costly for routine clinical use. The invasive methodology is not also sensitive enough for early detection and followup of patients. The objective is to develop a newgeneration diagnostic methodology for noninvasive detection of Helicobacter pylori infection in real-time using human breath analysis. In this project the main deliverable is to the development of a portable breath analyzer that can be used to detect the presence of the H. pylori infection in human stomach by analyzing some unique panels of molecular species in human breath. The technique can be used as a point of care (POC) instrument for routine clinical check-up. The proposed method is inexpensive, painless and avoids any contamination prone contact with the patient.

Status of prototype

  • Ready, "Pyro-Breath"

Salient Features

  • A simple diagnostic methodology for detection of Helicobacter pylori infection as well as ulcer disease using human breath analysis based on Residual Gas Analysis as opposed to commonly used Laser Spectroscopy.
  • It is non-invasive technique without endoscopy and biopsy tests.
  • It can identify presence of the infection in human stomach by following a simple protocol.
  • The system can be used even after the eradication of the infection or standard therapies.
  • The analyzer can be used for sample analysis on collected breath.
  • This innovation can be a better replacement for the existing methodologies.

Progress till date

  • Prototype system for field deployment has been developed.
  • Test on collected breath samples have been done on more than 100 patients in hospitals.
  • Fidelity established through parallel conventional measurement like endoscopy and related tests.
  • Necessary permissions approvals of new medical device rules have been initiated.

Technology Readiness Level (TRL)

TRL-7

Key Players (Collaboration)

 

Challenges

  • Availability of willing volunteers.
  • Obtaining necessary permissions for field use from statutory regulatory bodies.
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Objectives & Deliverables

Ammonia gas is toxic and hazardous pollutants in environment. Hence the ammonia sensor is used in food care, health care sectors, chemical and gas industries, testing laboratories. It finds its extensive use in fertilizer sectors, refrigeration systems/ cold storages, ammonia production plants, chemical petrochemical companies, food processing and so on. Most of the ammonia gas sensors are based on electrical and optical read outs that work at elevated temperature. Also available sensors need electronic peripherals to detect ammonia gas which make them costly and they are not disposable.

In this project we would like to make a cheap portable and flexible ammonia gas sensor that is based on simple detection technique of visual color change. It should work at room temperature and should have quick response. The sensor to be made desired to have high selectivity and high sensitivity to ammonia gas with relatively long shelf life.

Status of prototype

  • Ready, "Ammo-Watch"

Salient Features

  • Cost-effective
  • VISUAL SENSOR working at room temperature with fast response time (~10 sec).
  • No requirement of trained personnel for using.
  • Complete portability without a power supply or related accessories.
  • Good selectivity and very high sensitivity (~10ppm) and humidity insensitive during detection
  • Shelf life 6 months or more in dry storage condition at ambient temperature.
  • Easy manufacturability and components sourcing from local vendors.

Progress till date

  • A prototype (named "Ammo-Watch") has been developed as a wearable sensor band and tested in laboratory condition for detection of toxic ammonia gas in environment.
  • Selectivity, Sensitivity, Humidity Effect has been tested and found to be in desired range.
  • Stability of the sensor paper for shelf-life (in dry condition) for 6 months.

Technology Readiness Level (TRL)

TRL-7

Key Players (Collaboration)

 

Challenges

  • Standardization of the growth of the active material.
  • Active user protocol in extremely hazardous condition.
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Objectives & Deliverables

Thermal Analyzer is an instrument that can measure thermal parameters (in solids) like melting point, heat capacity, enthalpy of reaction. Thermal analyzer is used widely by chemists, physicists and materials scientists. Most thermal analysis equipments used in the country are immovable table top units that need main power in laboratory condition. The units are costly that prohibits their large scale use and have limited outreach.

In this project the deliverable a portable thermal analyzer (temperature range 30oC to 400oC) that can be carried in a simple brief case, with built in power pack and inexpensive computer where the data can be transferred through wireless or Wi-Fi.

Status of prototype

  • Ready, "Porto-Therma"

Salient Features

  • Low cost
  • Complete Portability without need for a power outlay nearby. Runs from a rechargeable power pack.
  • Uses low-cost computer on board with 7" touch sensitive pad with user friendly Graphic User Interface (GUI).
  • Easy manufacturability and components procured from local vendors through on line portals.
  • Data accessible by Wi-Fi / Wireless

Progress till date

  • A prototype (Porto-Therma) has been built and tested in laboratory condition using standard substances for measurement of melting point Tmp and Specific heat (Cp) in the stated temperature range.
  • The accuracy in Tmp determination achieved is ~5% and for Cp is ~ 10%.
  • Work is in progress to increase the accuracy and complete the Graphic User Interface with user feedback.
  • The prototype is ready for user/field testing.

Technology Readiness Level (TRL)

TRL-7

Key Players (Collaboration)

 

Challenges

  • Enhancing accuracy
  • Operation without standard aluminium pans
  • Development of capillary-based system.
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Objectives & Deliverables

The global statistics of under 5 child mortality rate is very alarming. Almost 20 children die per minute, mostly from preventive causes, almost all in underdeveloped/developing world. The leading causes include asphyxia, hypoxia, neonatal jaundice and anemia. Not only in children, anemia is a serious problem for women population particularly during pregnancy in India. Sickle cell anemia in tribal populations in India is also alarming. Traditional chemical and biological procedures for detection of these diseases through blood test are time consuming and results in the severity of disease increases to harmful level which may lead to casualty. Moreover, invasive blood sampling is painful and stressful for the neonates, resulting in blood loss and an increased risk of osteomyelitis and infection at the site of sampling. Blood sampling in environmentally harsh condition and conflict affected settings where army is deployed is also critical. Thus, an alternative test procedure is of immense importance.

Objectives:

  • Development of a non-contact non-invasive easy to use low cost optical device and associated software for measuring hemoglobin, bilirubin and oxygen saturation at point of care and immediate electronic transmission of test results.

Deliverables:

  • Prototype device capable of measuring all three body parameters at one go. Development of the indigenous software for report transmission

Status of prototype

  • Prototype ready

Salient Features

  • Efficient diagnoses of three parameters at one go without touching the subject (non-contact and non-invasive).
  • Ability to diagnose in Fragile and Conflictaffected Settings.
  • Ability of Immediate delivery of test results through cloud helping in online monitoring and e-health care.
  • Compatibility with mobile phone platform for data transceiving for treatment plan.
  • Low cost and no cost for consumables for economically challenging countries.
  • Requires involvement of minimally trained health-workers, preferably non-experts.

Progress till date

  • A prototype of the device is ready and being tested in three different hospitals in Kolkata for large scale evaluation.
  • Software is ready and working very well even for data transmission through cloud.
  • Patents are filed and clinical trial results for measurement of jaundice and anemia are published in international peer-reviewed journals.

Technology Readiness Level (TRL)

TRL-7

Key Players (Collaboration)

 

Challenges

  • Reaching to common people of our Country for the reduction of U5MR and MMR (maternal mortality rate).
  • Making multiple copies of the Device for the evaluation of the device across the country.
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Objectives & Deliverables

Quick and easy method to detect hazardous gases in work places and other installations is useful technology proposition. Desirable feature of such technology is high selectivity and specificity to hazardous gases.

In this project we are working to develop highly sensitive (less than 1ppm level) yet inexpensive sensors operable at room temperature. The sensors will be put with measurement device allowing data access through Wi-Fi or wireless routes.

Status of prototype

  • Proof of concept established for NO and NH3 gases. Prototype with read-out being built for remote read-out accessibility

Salient Features

  • Low cost and easy read out with remote access.
  • Innovative use of easily available nanomaterials.
  • Portable readout devices
  • Room temperature operation and low power consumption.
  • Highly selective and sensitive
  • Easy to use and disposable.
  • Easy production method and does not need costly capital investment.

Progress till date

  • Proof of concept established for two gases namely NO and NH3. For NH3 sensor the sensitivity achieved is ≤ 1ppm and for NO gas the sensitivity achieved is 0.5 ppm (for both gases).
  • High selectivity established in both sensors that it does not respond to gases like other oxides of nitrogen, CO2 CH3, moisture, Ethanol, Acetone etc.
  • The NH3 sensor is grown on paper.
  • Sensor performance being optimized.
  • Portable detection electronics being fabricated for making complete prototype.

Technology Readiness Level (TRL)

TRL-4

Key Players (Collaboration)

 

Challenges

  • Reproducible materials synthesis in large scale.
  • Patterning and control of device manufacture.
  • Sensitivity limits of electronics.
  • Development of portable and hand held electronics for use in hazardous environment.
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Objectives & Deliverables

This is a hand held device that can easily detect organic and inorganic adulterants present in milk via property measurements. The proposed kit would be simple enough to be operated by non technical persons in open environment and at all weather condition. This will be field useable and not required testing in a specialized remote lab. The main objective here is to prevent mass consumption of adulterated milk.

Status of prototype

  • Proof of concept established, prototype is being assembled.

Salient Features

  • Handheld and user friendly.
  • Inexpensive
  • Appropriately sized for transportation and operation in open environment.
  • Fast and reliable.

Progress till date

  • The proof of concept has been established through laboratory testing on branded milk as well as on adulterated milk sample.
  • The electronic circuit has been fabricated.
  • Reproducible data obtained from fabricated circuit.
  • Work in progress for optimization and precision.
  • Final device prototype is being finalized.

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

 

Challenges

  • Secured environment for collection of milk samples at milk booths and field testing.
  • Calibration of quality parameter during winter and non winter seasons.
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Objectives & Deliverables

To fulfill our energy demands, the release of the greenhouse gas CO2 has exponentially increased day by day because of the growing dependence on the fossil fuel. As a consequence, the atmospheric concentration of CO2 (currently ~400 ppm) has been progressively increasing since the beginning of the industrial revolution. The growing concern about the consequences of higher concentration of CO2 is not only the global warming but also the severe effect on the growth and physiology of the living beings. Thus, the global attention has been focused on the efficient capture and subsequent sequestration of CO2 from the atmosphere.

Capture of gas molecules in porous solids depends on the two factors: (i) kinetic diameter of the gas molecule and size of the pores, and (ii) molecular level interaction between the gases and the materials. Porous adsorbents synthesized from waste materials or silica can be used for CO2 capture. Based on these ideas, we would like to develop porous adsorbents for trapping CO2 from closed environments under oxidative condition.

Status of prototype

  • Proof of concept established

Salient Features

  • Usage of waste material as precursor to make cost-effective adsorbents.
  • Porous silica having high specific surface area.
  • Large scale synthesis to capture the massive CO2 emission.
  • Heteroatom doping significantly increases CO2 adsorption capacity.
  • Removal of CO2 from closed environment.

Progress till date

  • Synthesis and characterization of porous materials.
  • Studying the gas adsorption efficacy.
  • Testing efficacy in oxidative atmosphere.
  • Designing the synthesis process to make it compatible with up-scaling.
  • Working on the prototype development to be used for CO2 capture

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

 

Challenges

  • Large-scale processing of porous materials.
  • Identification of industries to test the sample efficacy.
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Objectives & Deliverables

Piezoelectric energy harvesting provides solution to converting the wasted mechanical energy into electrical energy. Flexible piezoelectric nano - generator has vital importance for self-powered nano / micro-systems. Aim of this project is to deliver a low cost small scale portable power generation that can continuously charge a battery for health care devices and other similar applications.

Status of prototype

  • Proof of concept established, prototype being assembled

Salient Features

  • Grown by low cost chemical method.
  • PZT nanowire of designed morphology that optimizes the voltage generation.
  • Piezo-generator fabricated on a flexible substrate enabling flexure mode for generation.
  • Manufacturing compatible with low cost processes.

Progress till date

  • Optimized growth of PZT nanowires with desired morphology and chemical constituents.
  • Achieved very high dielectric constants in the PZT nanowires.
  • Fabricated devices to establish proof of concept.
  • Achieved voltage generation ~ 1V [~20 nW power] with moderate bending (radius of curvature ~3.5 cm).

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

 

Challenges

  • Achieve reproducibility in materials synthesis and up-scaling.
  • Shelf-life of material.
  • Optimize design to enhance the output voltage to 1.5 V.
  • Enhance the output power in mW and make it compatible with use.
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Objectives & Deliverables

The stated objective of the work is to develop a remote acting photo actuated catheter that is minimalistic in design, should be self-adjusting and unique. The atherectomy would be performed with an actuated micro shovel made of active material in front of the catheter, with another unique distal embolization protection device.

Worldwide the problem of blockage of blood flow through the arteries, especially coronary or carotid ones, is leading to serious consequences. This happens due to building up of the plaques or cholesterol, wax etc. deposits in the arteries, leading to heart attacks or strokes. While the standard ways are Coronary Artery Bypass Graft and Percutaneous Coronary Intervention, the end result is either too time consuming or has a problem of needing reintervention after some time. We are trying an alternative route through atherectomy in arteries with distal embolization protection device, using the photomechanical actuation effect to build a small scrapper in front of the catheter. The light tube here would double up both as a guide and a conduit for carrying the controlling light pulses.

Status of prototype

  • Design and test stage

Salient Features

  • A unique device for protection of distal embolization inside the flowing fluid.
  • Remote acting photo actuated catheter that is minimalistic in design.
  • Time saving and minimal reintervention.

Progress till date

  • Equivalent force of mechanical actuation is being measured.
  • Samples fabrication and characterizations are in progress.
  • Development and testing of different smart materials for the desired effect

Technology Readiness Level (TRL)

TRL-3

Key Players (Collaboration)

 

Challenges

  • Simulation for in-vitro effect.
  • Property-optimization and the stability of active materials.
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Objectives & Deliverables

A recent survey by Food Safety and Standards Authority of India (FSSAI) reveals that unbranded local milk is high in contaminants, posing a serious health risk to consumers. Water turns out to be the most common adulterant in milk, and it reduces the nutritional value of milk. It could be a health risk to consumers, if water contaminated with like pesticides, heavy metal, etc. Other contaminants like detergent, urea, starch, glucose, formalin are frequently used as adulterants, which also pose a high risk to health. Amount of essential components of milk like fat, protein, lactose, casein, etc. are now modified due to such adulterants.

The deliverable of this project will be a low-cost NIR spectrometer that will be tuned on particular bands of milk spectrum. The Near-Infrared (NIR) spectrometer will be capable of giving the information about more than one constituent component of milk, quantitively. In market, there are different types of lactometers available but they give only the information about water but here the NIR spectrometer will be capable of giving information about other constituent components (e.g., fat, protein etc.).

Status of prototype

  • Prototype is in design stage

Salient Features

  • Optical / NIR spectroscopic instrument for understanding milk adulterants.
  • Ability of giving quantitative information about more than one constituent component of milk.
  • Low-cost, compact and portable for user friendly.

Progress till date

  • Laboratory studies of milk spectra in the NIR region provide a very good correlation of different bands (e.g., fat, protein) with major adulterant water, which is encouraging.
  • Quantitative measurement of adulterant water and their impact on other constituents in milk is done. Laboratory based prototype design work of NIR spectrometer has been done using commercially available optical design software ZEMAX.
  • The work is in progress to fasten the correlation of bands firmly.

Technology Readiness Level (TRL)

TRL-2

Key Players (Collaboration)

 

Challenges

  • Very weak NIR bands of fat and protein in presence of strong water bands in this region.
  • Low-cost NIR instrument.
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Objectives & Deliverables

Search for novel materials with desired and engineered properties is a multi-dimensional problem which demands optimization of different materials properties. Understandably, experimental discovery is limited by high costs and timeconsuming procedure of synthesis. A natural alternative is the emerging area of computational materials science, namely, "high throughput" (HT) computational materials design using multi-scale simulation techniques.

Status of prototype

  • Progress has been made in terms of prediction of new materials

Salient Features

  • Prediction of new magnetic materials.
  • Study of alloys at nanoscale.
  • High manganese (Mn) content steel.

Progress till date

  • Prediction of six new magnetic compounds having challenging magnetic and conduction properties.
  • Understanding structure of Fe-Cr nanoalloy.
  • Development of Software tool for property and performance prediction of high Mn content steel.

Technology Readiness Level (TRL)

TRL-2

Key Players (Collaboration)

 

Challenges

  • Testing of prediction – connection to synthesis.
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Objectives & Deliverables

Metal-Organic Frameworks (MOFs) are a new class of porous materials which have gained major interest due to their potential applications as absorbent. MOFs have recently emerged as an important class of porous organic-inorganic hybrid materials, in which their pores can be functionalized by changing suitable organic ligands.

In order to achieve the maximum storage capacity of gases, we have aimed to synthesize suitable conjugated long organic ligands to form MOFs for better gas sorption as well as sensing of hazardous chemicals based on luminescence properties.

Status of prototype

  • Proof of the concept is being established

Salient Features

  • Crystalline, highly ordered solids.
  • Extremely high porosity.
  • Extremely high surface area.
  • Very low density.
  • Structurally flexible.

Progress till date

  • Synthesized and characterized of suitable conjugated long organic ligands in our lab.
  • By changing many organic linkers or metal cluster and reaction condition, synthesized one crystalline metal-organic framework successfully. by hydrothermal process, is characterized by powder X-ray diffraction.
  • Determining the single crystal structure of the resultant product for further studies. Determining the single crystal structure of the resultant product for further studies.

Technology Readiness Level (TRL)

TRL-1

Key Players (Collaboration)

 

Challenges

  • Large-scale synthesis of MOFs materials.
  • Thermal stability of the MOFs materials (more than 500°C).
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